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A GLP-1R agonist/GIPR antagonist peptide is theoretically possible but few full-length GIP-like antagonists were reported, 60 therefore it requires an array of attempts, at least an alanine-scan experiment of GIP with measuring of affinity

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J Bioenerg Biomembr 48:591598 Demarest TG, Schuh RA, Waddell J, McKenna MC, Fiskum G (2016) Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy